Most of the body's phosphorus is combined with calcium within the skeleton, but about 15% exists in the blood. Dietary phosphorus is efficiently absorbed, so low phosphorus caused by dietary deficiency is unlikely in the absence of a malabsorption syndrome (inadequate absorption of nutrients in the intestinal tract) for individuals on a normal diet. Phosphorus is an important test used to evaluate several diseases. High levels may occur in Bone metastasis, Hypocalcemia, Hypoparathyroidism, Liver disease, Renal failure, Sarcoidosis, and increased dietary intake. Lower-than-normal levels may indicate Diabetic ketoacidosis, Hypercalcemia, Hyperinsulinism, Hyperparathyroidism, or inadequate dietary intake of phosphorus or Vitamin D.
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