CA-125 is a substance produced by the fallopian tubes, the endometrium, and the lining of the abdominal cavity (peritoneum). See an illustration of the female reproductive system. CA-125 is used as a tumor marker—an indicator of some types of cancer, especially ovarian cancer. The amount of CA-125 in a woman's blood and body fluids often increases when cancer of the ovaries is present. However, it is important to know that: · Other conditions can also cause increased levels of CA-125, including pregnancy, menstruation, some non-ovarian cancers, and some noncancerous disorders. · CA-125 levels do not rise above the normal range in all women who have ovarian cancer. · CA-125 levels often do not rise until the cancer is in an advanced stage. CA-125 is a cancer tumor marker that is useful as a marker for ovarian cancer, but may be elevated in other cancers as well. It is not able to distinguish between benign and malignant ovarian tumors, and is best used with other cancer tumor markers.
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