Apolipoprotein A-I comprises 60% to 70% of the protein content of HDL. Apolipoprotein A-I is involved in the transport of cholesterol from tissues to the liver where it is metabolized. Decreased serum HDL cholesterol levels have been reported to correlate with increased risk of coronary artery disease (CAD). However, Apo A-I has been suggested as a better discrimination of CAD than HDL. Apo A-I levels also correlate with survival rates or risk factors for patients with myocardial infarction (heart attack) and peripheral vascular disease (hardening of the arteries). Measurement of Apo A-I may also aid in the diagnosis of Tangier disease (absence of alpha-lipoprotein).
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