Increased IgA may be produced in disorders of the lymphatic system.especially cancers of white blood cells that produce antibodies (multiple myeloma) and "Mediterranean" lymphoma involving the colon. An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces.where IgA is largely produced. Patients with genetic IgA deficiency are prone to autoimmune diseases, and may develop antibody to IgA. IgA levels may rise with exercise.
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